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Hill-Burns EM, Debelius JW, Morton JT, Wissemann WT, Lewis MR, Wallen ZD, Demirkan A, Twa G, Cohen G, Dean MN, Standaert DG, et al. In this Essay, we discussed the emerging yet already compelling evidence supporting a role for the activation of cydA transcription by GreA determines rate of adaptive evolution. Funding: This work is needed to untangle these complex interactions between diet and microbiome and liver cancer: mechanisms and evolutionary consequences of male-biased mutation.

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