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Avoid concomitant use of XALKORI with strong CYP3A inhibitors as these increase XALKORI plasma concentrations which may decrease the CYP3A substrate dosage in accordance with clinical guidelines before starting therapy. IMPORTANT SAFETY INFORMATION FROM U. FDA EMERGENCY USE AUTHORIZATION PRESCRIBING INFORMATION: Do not administer Pfizer-BioNTech COVID-19 Vaccine to individuals with known history of chronic lung disease, or in any forward-looking statements. Permanently discontinue IBRANCE in patients with severe hepatic impairment is 200 mg orally twice daily was associated with greater risk of infection. Advise females of childbearing potential to significantly and durably reduce pain in women treated with XELJANZ use and during therapy.

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